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目的探讨血清孕酮与绒毛膜促性腺激素联合检测在妊娠早期中的诊断及治疗意义。方法分别采用ECL/RIA技术对300例早期妊娠者血清孕酮与绒毛膜促性腺激素进行检测。结果血清P值>60nmol/L,血β-HCG>50mIU/ml患者85例,占28.33%,经卧床休息,未用药治疗,均胚胎发育正常;血清P值在30~60 nmol/L,血β-HCG 10~50/mIU/ml患者155例,占51.67%,经黄体酮与绒毛膜促性腺激素保胎治疗后均胚胎发育正常;血清P值<30 nmol/L,血β-HCG<10mIU/ml患者45例,占15%,终止妊娠者均可见清除宫内组织物中几乎不见新鲜绒毛并伴有不同程度的陈旧性出血;血清孕酮与β-HCG上升不同步患者15例,占5.0%,均最终难免流产。结论对于妊娠早期者动态观察血清孕酮与β-HCG,对于妊娠结局的预测及指导治疗具有重要的临床价值。
Objective To investigate the diagnostic and therapeutic value of serum progesterone and chorionic gonadotropin combined detection in early pregnancy. Methods The levels of serum progesterone and chorionic gonadotropin in 300 cases of early pregnancy were detected by ECL / RIA respectively. Results Serum P value> 60nmol / L, blood β-HCG> 50mIU / ml 85 patients, accounting for 28.33%, after bed rest, no medication, all embryonic development was normal; serum P value in 30 ~ 60 nmol / L, There were 155 patients (51.67%) with β-HCG 10-50 / mIU / ml, normal embryo development after progesterone and chorionic gonadotrophin miscarriage treatment, serum P value <30 nmol / L and blood β-HCG < 45 cases of 10mIU / ml patients, accounting for 15%, the termination of pregnancy were visible in the intrauterine tissue was almost no fresh villi accompanied by varying degrees of old bleeding; serum progesterone and β-HCG rise in patients with asynchronous in 15 cases, Accounting for 5.0%, are ultimately inevitable abortion. Conclusion The dynamic observation of serum progesterone and β-HCG in early pregnancy has important clinical value in predicting pregnancy outcome and guiding treatment.