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目的 观察增生性玻璃体视网膜病变 (proliferative vitreoretinopathy,PVR) C、D两级视网膜前膜 (epiretinal membranes,ERM)和培养的人视网膜色素上皮 (retinal pigment epithelium,RPE)细胞中肝细胞生长因子受体 (hepatocyte growth factor receptor,HGFR)的表达情况。 方法 采用免疫组织化学染色方法对 15例复杂孔源性视网膜脱离患者玻璃体切割术中剥离的 ERM以及培养的人 RPE细胞中HGFR的表达情况进行观察。 结果 在 6例 PVR C级和 9例 PVR D级 ERM标本中分别有 5、7例呈HGFR阳性表达 ;培养的 RPE细胞胞浆中 HGFR呈阳性表达。 结论 肝细胞生长因子有可能参与了PVR的病理过程
Objective To observe the expression of hepatocyte growth factor receptor (HGF) in proliferating vitreoretinopathy (PVR) C and D epiretinal membranes (ERM) and cultured human retinal pigment epithelium (RPE) Hepatocyte growth factor receptor, HGFR) expression. Methods The expression of HGFR in 15 cases of rhegmatogenous retinal detachment after vitrectomy and the cultured human RPE cells were observed by immunohistochemical staining. Results In 6 cases of PVR grade C and 9 cases of PVR grade D ERM specimens, 5 and 7 cases were positive for HGFR expression. The expression of HGFR in the cytoplasm of cultured RPE cells was positive. Conclusion Hepatocyte growth factor may participate in the pathological process of PVR