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研究高尿酸血症患者血浆中脑钠肽水平与心房颤动(简称房颤)的关系。选择2014年6月~2015年10月,大连大学附属中山医院住院的阵发性房颤组(56例)、持续性房颤组(52例)作为房颤组,同期选择无房颤临床症状的患者50例作为对照组,记录各组患者的年龄、脑钠肽水平以及血清尿酸水平。分析对照组、阵发性房颤组以及持续性房颤组患者血尿酸以及血清中脑钠肽含量的差异,同时采用logistic回归分析各因素的相关性,探讨血尿酸以及脑钠肽与房颤的相关关系。结果显示,对照组患者血尿酸水平(310.5±67.9)μmol/L与阵发性房颤组患者(313.3±78.3)μmol/L差异无统计学意义(t=1.02,P=0.61),而持续性房颤患者血尿酸水平(383.1±73.6)μmol/L较对照组(t=4.19,P<0.01)和阵发性房颤组(t=4.77,P<0.01)提高,差异均有统计学意义。阵发性房颤组患者血清脑钠肽水平(299.7±46.5)mg/L以及持续性房颤组(383.1±73.6)mg/L较对照组(37.2±9.5)mg/L升高,差异均有统计学意义(t=21.20、29.10,均P<0.01)。logistic回归分析表明尿酸水平以及血清中脑钠肽水平是房颤的独立危险因素,监测血清脑钠肽含量的变化对房颤的早期诊断有重要意义。
To study the relationship between plasma brain natriuretic peptide and atrial fibrillation (AF) in patients with hyperuricemia. Choose from June 2014 to October 2015, Zhongshan Hospital Affiliated to Dalian University paroxysmal atrial fibrillation group (56 cases), persistent atrial fibrillation group (52 cases) as atrial fibrillation group, the same period without the clinical symptoms of atrial fibrillation Of 50 patients as control group, record the age of patients in each group, brain natriuretic peptide levels and serum uric acid levels. Analysis of the control group, paroxysmal atrial fibrillation group and persistent atrial fibrillation patients with serum uric acid and serum brain natriuretic peptide content differences, while the use of logistic regression analysis of the correlation between various factors to explore serum uric acid and brain natriuretic peptide and atrial fibrillation The relationship between. The results showed that the serum uric acid level in the control group (310.5 ± 67.9) μmol / L was not significantly different from that in the patients with paroxysmal atrial fibrillation (313.3 ± 78.3) μmol / L (t = 1.02, P = 0.61) The level of serum uric acid in patients with atrial fibrillation (383.1 ± 73.6 μmol / L) was significantly higher than that in control group (t = 4.19, P <0.01) and patients with atrial fibrillation (t = 4.77, P <0.01) significance. The levels of serum brain natriuretic peptide in patients with paroxysmal atrial fibrillation (299.7 ± 46.5) mg / L and those in persistent atrial fibrillation (383.1 ± 73.6 mg / L) were significantly higher than those in the control group (37.2 ± 9.5) mg / L There was statistical significance (t = 21.20,29.10, all P <0.01). Logistic regression analysis showed that uric acid level and serum brain natriuretic peptide level were independent risk factors for atrial fibrillation. Monitoring the changes of serum brain natriuretic peptide content is of great significance for the early diagnosis of atrial fibrillation.