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目的:探讨中医个性化干预治疗类风湿性关节炎的临床疗效,并观察患者生活质量的改善情况。方法:选择近4年就诊的类风湿性关节炎患者82例作为研究对象,随机分为对照组和观察组各41例,对照组给予口服来氟米特片,前3天50 mg/次,之后根据病情给予维持剂量10 mg/次或20 mg/次,1次/d,1个月为1个疗程,连续治疗3个疗程;观察组在对照组的基础上根据患者脏腑气血阴阳辨证结果给予中药汤剂治疗,1个月为1个疗程,连续治疗3个疗程。结果:观察组的总有效率为92.68%显著高于对照组的70.73%,两组相比差异具有统计学意义(P<0.05);观察组在晨僵时间、关节肿胀、关节压痛等方面均优于对照组,差异有统计学意义(P<0.05);对照组和观察组患者肝功能、肾功能各项指标治疗前后无明显变化,对患者进行随访发现,无论是对照组还是观察组,患者的生活质量均得到了提高。通过患者口述,观察组患者的关节肿胀以及睡眠情况改善情况均优于对照组。结论:中医个性化干预治疗类风湿性关节炎效果显著,且不良反应少,值得在临床上推广使用。
Objective: To explore the clinical curative effect of personalized intervention of TCM on rheumatoid arthritis and to observe the improvement of patients’ quality of life. Methods: A total of 82 rheumatoid arthritis patients selected for the past 4 years were randomly divided into control group and observation group (n = 41). Oral leflunomide tablets were given to the control group, 50 mg for the first 3 days, After the treatment according to the condition to maintain the dose of 10 mg / time or 20 mg / time, 1 / d, 1 month for a course of treatment for 3 courses of continuous treatment; the observation group in the control group based on the patients viscera qi and yang The results given Chinese medicine decoction treatment, 1 month for a course of treatment, continuous treatment of 3 courses. Results: The total effective rate of the observation group was 92.68%, which was significantly higher than that of the control group (70.73%), the difference between the two groups was statistically significant (P <0.05). The observation group had significant differences in morning stiffness time, joint swelling, joint tenderness (P <0.05). There was no significant change in the indexes of liver function and renal function between the control group and the observation group before and after treatment. The patients were followed up and found that no matter in the control group or the observation group, The quality of life of patients has been improved. Through patient orality, the observed group of patients with joint swelling and improvement of sleep conditions were better than the control group. Conclusion: Chinese medicine personalized intervention for the treatment of rheumatoid arthritis significant effect, and fewer adverse reactions, it is worth promoting the clinical use.