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用不同剂量（5，10，20，50，100mg／kg）甲醛经腹腔注射染毒SD大鼠后24小时，以及10mg／kg染毒后2，6，24小时收集大鼠血和肝脏。对样品的测定结果显示，红细胞SOD活性，全血GSH－PX活性，红细胞内谷胱甘肽含量以及血浆与肝组织MDA浓度等五项指标与染毒剂量均有不同程度相关，其中红细胞 SOD对甲醛最为敏感，5mg／kg时就比对照组有明显降低，在时间效应关系中可以见到红细胞内SOD活性和全血GSH－PX活性染毒（10mg／kg）后24小时内随时间延长而逐渐降低。染毒后2小时血浆中MDA浓度最高，红细胞内GSH含量最低，两者在染毒后24小时基本上恢复到对照组水平。结果提示，甲醛可以启动体内脂质过氧化反应，损伤自由基和活性氧的清除系统。
Rat blood and liver were harvested 24 h after intraperitoneal injection of SD rats at various doses (5, 10, 20, 50, 100 mg / kg) formaldehyde and 2, 6, 24 hrs after 10 mg / kg exposure. The results showed that SOD activity of erythrocytes, GSH-PX activity of whole blood, glutathione content of erythrocytes, and MDA concentration of plasma and liver tissue were all correlated with exposure dose to varying degrees, among which erythrocyte SOD Formaldehyde was the most sensitive, 5mg / kg significantly lower than the control group, the time effect can be seen within the erythrocyte SOD activity and whole blood GSH-PX activity (10mg / kg) within 24 hours after prolonged Gradually decreases. Two hours after exposure to the highest plasma concentrations of MDA and lowest levels of GSH in erythrocytes, both of them returned to control levels 24 hours after exposure. The results suggest that formaldehyde can start the body lipid peroxidation, damage free radicals and reactive oxygen species scavenging system.