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目的:探讨血清甲胎蛋白(AFP)、癌胚抗原199(CEA)与肿瘤抗原(CA199)联合检测对原发性肝癌的早期诊断价值。方法:应用电化学发光法联合测定51例原发性肝癌和75例良性肝病(肝硬化、慢性肝炎)患者血清AFP、CEA与CA199的水平。结果:肝癌组血清AFP、CEA和CA199阳性率分别为74.5%、49.0%和45.1%,显著高于良性肝病组(P<0.05);三项联合对肝癌阳性率提高至92.2%、与单项检测相比均有明显差异。结论:3项肿瘤标志物对肝肿瘤的良恶性辅助诊断及鉴别诊断具有一定应用价值,联合检测可以提高原发性肝癌的阳性诊断率。
Objective: To investigate the value of serum AFP, CEA and CA199 in the early diagnosis of primary liver cancer. Methods: The levels of serum AFP, CEA and CA199 in 51 patients with primary hepatocellular carcinoma and 75 patients with benign liver disease (cirrhosis, chronic hepatitis) were determined by electrochemiluminescence. Results: The positive rates of serum AFP, CEA and CA199 in hepatocellular carcinoma were 74.5%, 49.0% and 45.1%, respectively, which were significantly higher than those in benign liver disease group (P <0.05). The positive rate of hepatocellular carcinoma was 92.2% Compared with all significant differences. CONCLUSION: The three tumor markers have certain value in the diagnosis and differential diagnosis of benign and malignant liver tumors. Combined detection can improve the positive diagnosis rate of primary liver cancer.