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目的探讨蒙脱石散洗胃治疗百草枯中毒的疗效。方法选择笔者所在医院明确诊断为百草枯中毒的患者为研究对象。随机分试验组47例和对照组47例,试验组予蒙脱石散洗胃,对照组予生理盐水洗胃。随访3个月,比较试验组和对照组死亡、急性呼吸窘迫综合征(ARDS)、急性肾损伤(ARF)、急性中毒性肝炎(ATH)发生率及多脏器功能衰竭(MODS)出现时间和ARDS出现时间的差别。结果①试验组与对照组在年龄、性别构成、服毒剂量和服毒至就诊时间等方面比较,差异无统计学意义(P>0.05);②试验组死亡、ARDS、ARF发生率显著低于对照组,差异有统计学意义(P<0.05);试验组MODS出现时间和ARDS出现时间显著晚于对照组,差异有统计学意义(P<0.01)。结论蒙脱石散洗胃治疗百草枯中毒疗效优于生理盐水洗胃。
Objective To investigate the curative effect of montmorillonite and gastric lavage in the treatment of paraquat poisoning. Methods Select the author’s hospital diagnosed as paraquat poisoning patients as the research object. Randomly divided test group 47 cases and control group 47 cases, the experimental group to montmorillonite scattered gastric lavage, the control group to saline lavage. After 3 months of follow-up, the incidences of death, acute respiratory distress syndrome (ARDS), acute renal injury (ARF), acute toxic hepatitis (ATH) and multiple organ failure (MODS) were compared between the experimental group and the control group ARDS appear the difference of time. Results ① There was no significant difference between the experimental group and the control group in terms of age, gender composition, dose of poisoning and time from taking drugs to visiting. (2) The death of the experimental group, the incidence of ARDS and ARF was significantly lower than that of the control group , The difference was statistically significant (P <0.05). The occurrence time of MODS and the appearance time of ARDS in the experimental group were significantly later than those in the control group, the difference was statistically significant (P <0.01). Conclusion Montmorillonite powder gastric lavage treatment of paraquat poisoning is better than saline gastric lavage.