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目的：探讨肺鳞状细胞癌组织ｐ５３ 蛋白的过度表达与肿瘤生物学行为及预后的关系。方法：应用单克隆抗 ｐ５３ 抗体对石蜡包埋的肺癌组织标本进行免疫组织化学染色。结果：６８ 例获随访的肺鳞状细胞癌病例中有 ４４ 例 ｐ５３ 表达阳性，总阳性率为 ６４７％ ，且其阳性率随肿瘤病理分级、临床分期的增高而增加（ Ｐ＜ ００５）；与术后５ 年存活情况有关（ Ｐ＜ ００５）。结论：提示ｐ５３ 基因的异常表达在肺鳞状细胞癌的发展过程中起重要作用，对肺鳞状细胞癌病人的预后判定有一定意义。
Objective: To investigate the overexpression of p53 protein in lung squamous cell carcinoma and its relationship with tumor biological behavior and prognosis. METHODS: Immunohistochemical staining of paraffin-embedded lung cancer specimens was performed using a monoclonal anti-p53 antibody. RESULTS: Of the 68 cases of lung squamous cell carcinoma who were followed up, 44 cases had positive expression of p53, with a total positive rate of 64.7%, and the positive rate increased with the increase of tumor pathological grade and clinical stage (P<0). 05); related to 5-year survival after surgery (P<005). Conclusion: It is suggested that the abnormal expression of p53 gene plays an important role in the development of lung squamous cell carcinoma and has a certain significance for the prognosis of patients with squamous cell carcinoma of the lung.