论文部分内容阅读
目的：研究抗ＣＤ３－抗胶质瘤双特异性抗体（双抗）对裸鼠体内人脑胶质瘤生长的影响。方法：动物分为６组，实验组系双抗治疗组，其余为不同的对照组，采用人脑胶质瘤裸鼠模型ＮＨＧ－１，分别观察各组中肿瘤的出现、生长及宿主的生存情况。结果：在实验组中，肿瘤出现的平均潜伏期、肿瘤细胞生长周期时间以及动物的生存期均比各对照组延长（Ｐ＜０．０５或Ｐ＜０．０１）；肿瘤增殖曲线显示，经几周缓慢生长后，各对照组先后进入快速生长期，而经双抗治疗的实验组，肿瘤始终处于缓慢生长状态。结论：抗ＣＤ３－抗胶质瘤双特异性抗体可以延缓人脑胶质瘤在动物体内的生长速度，具有临床应用潜力。
Objective: To study the effect of anti-CD3-anti-glioma bispecific antibody (double antibody) on the growth of human glioma in nude mice. METHODS: The animals were divided into 6 groups. The experimental group was a double-antibody treatment group and the rest were different control groups. The human brain glioma nude mouse model NHG-1 was used to observe the appearance, growth and survival of the tumor in each group. Happening. RESULTS: In the experimental group, the average latency of the tumor, the growth cycle of the tumor cells, and the survival time of the animals were all longer than those of the control group (P<0.05 or P<0.01). The tumor proliferation curve showed that After a week of slow growth, each control group entered a rapid growth phase, whereas in the experimental group treated with double antibodies, the tumor was always in a state of slow growth. Conclusion: The anti-CD3-anti-glioma bispecific antibody can delay the growth rate of human glioma in animals and has clinical application potential.