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为评价还原型谷胱甘肽(GSH)潜在的心肌保护作用,作者随机选择体重120—130克的雌鼠在标准实验室条件下进行了研究。阿霉素(DXR)静脉给药,每周1次,3mg/kg,共给4次;每次注射DXR 前10分钟和注射后2小时静脉注射GSH250或500mg/kg,每周总剂量500或1000mg/kg。对照组每次注射与治疗组同等容量的生理盐水(2ml/kg)。以心电图监护心肌毒性的发生(QT 间期),并在最后1次注射DXR后5周分离出心房,测定其收缩性,对同时制成的左
To assess the potential myocardial protection of reduced glutathione (GSH), the authors randomly selected females weighing 120-130 g under standard laboratory conditions. Doxorubicin (DXR) is administered intravenously once a week at 3 mg / kg for 4 times; GSH 250 or 500 mg / kg intravenously 10 minutes prior to each DXR injection and 2 hours post injection, with a total weekly dose of 500 or 1000mg / kg. The control group was injected with the same volume of normal saline (2ml / kg) as the treatment group. Cardiac toxicity was monitored by electrocardiogram (QT interval), and the atria were isolated 5 weeks after the last injection of DXR to determine their contractility. At the same time, left