环孢菌素A(CyA)是一种免疫抑制剂,但有肾毒性,且常引起高血压,故常需降压治疗,其应用受到限制。这两种主要不良反应的可能机理之一是与CyA增强血管平滑肌对血管收缩剂刺激的反应性有关。据Bossal-ler等研究,CyA致血管张力增加是由于内皮功能障碍减弱了内皮对抗血管收缩剂刺激的保护作用。给大鼠大剂量CyA,其离体主动脉生成前列环素减少,内皮舒张因子(EDRF)介导的反应减弱。己酮可可碱(PTX)是用于治疗周围血管疾病、改善血液流变学的药物,其有益作用与增加前列环素的合成和可能增强EDRF介导的反应有关。这两种有效的 Cyclosporine A (CyA) is an immunosuppressive agent, but nephrotoxic, and often cause high blood pressure, so often need antihypertensive treatment, its application is limited. One of the possible mechanisms of these two major adverse reactions is associated with the reactivity of CyA to enhance vascular smooth muscle stimulation of vasoconstrictors. According to Bossal-Ler and other studies, CyA induced vascular tension increase is due to endothelial dysfunction weakened endothelial protection against vasoconstrictor stimulation. Rats given high doses of CyA, its isolated aorta generated prostacyclin reduction, endothelial relaxation factor (EDRF) -mediated response was weakened. Pentoxifylline (PTX) is a drug used to treat peripheral vascular disease and to improve hemorrheology, with beneficial effects associated with increased prostacyclin synthesis and possibly enhanced EDRF-mediated responses. Both are effective