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食道、胃底静脉曲张破裂出血是肝硬化门静脉高压病人死亡的主要原因之一。1980年Lebrec等报道应用心得安治疗可使肝硬化伴门脉高压患者的门静脉压明显下降,并提出可用以防治门脉高压合并食管静脉曲张破裂出血,双盲对照治疗观察,显示心得安治疗组出血复发率和死亡率明显降低。心得安的药理作用心得安是一种非选择性β肾上腺素能受体阻滞剂,能竞争性地与β_1及β_2肾上腺素能受体结合。当与β_1受体结合时,可使心,肌收缩力减弱,传导延缓,不应期延长,从而
Esophageal and gastric variceal bleeding is one of the major causes of death in cirrhotic patients with portal hypertension. 1980 Lebrec et al reported that the application of propranolol therapy can significantly reduce the portal hypertension in patients with cirrhosis and portal hypertension and proposed for the prevention and treatment of portal hypertension combined with esophageal variceal bleeding, double-blind control treatment, Hemorrhage recurrence rate and mortality was significantly reduced. Empiric Pharmacological Effects Diazepam is a nonselective β-adrenergic receptor blocker that competes competitively with β_1 and β_2 adrenergic receptors. When β_1 receptor binding, can make the heart, muscle contractility weakened, conduction delay, refractory period, thus