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目的 :观察降钙素基因相关肽 (CGRP)在成年豚鼠耳蜗中的分布。方法 :采用免疫组织化学 ,光镜观察的方法 ,对CGRP在豚鼠耳蜗中的分布进行研究。结果 :CGRP阳性反应物分布于螺旋神经元 ,骨螺旋板神经孔 ,内毛细胞、外毛细胞与外支持细胞交界区 ,螺旋韧带血管纹。结论 :CGRP广泛分布于豚鼠耳蜗 ,是耳蜗传出神经系统重要的神经递质或神经调质 ,CGRP可能通过调节螺旋神经元、毛细胞和支持细胞等影响听功能 ,也可能影响耳蜗的血流
Objective: To observe the distribution of calcitonin gene related peptide (CGRP) in the cochlea of adult guinea pigs. Methods: The distribution of CGRP in guinea pig cochlea was studied by immunohistochemistry and light microscope. Results: CGRP positive reactants distributed in the spiral neurons, the bone spiral plate nerve hole, the inner hair cells, the outer hair cells and the outer support cell junction, the spiral ligament vascular pattern. CONCLUSION: CGRP is widely distributed in the cochlea of guinea pigs and is an important neurotransmitter or neuromodulator in the cochlear nervous system. CGRP may affect the hearing function by regulating the spiral neurons, hair cells and supporting cells, and may also affect the cochlear blood flow