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目的:探究炎症反应对类风湿关节炎患者动脉粥样硬化的影响。方法:观察组选取2015年1月至2016年4月收治的45例类风湿关节炎患者;对照组选取45例体检健康的志愿者。检测并记录两组血脂和炎症因子水平,分析炎症因子与动脉粥样硬化指数(AI)的相关性。结果:观察组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、AI水平均显著高于对照组(P<0.05);三酰甘油(TG)水平比对照组高,但差异无统计学意义;高密度脂蛋白胆固醇(HDL-C)水平显著低于对照组(P<0.05)。观察组C反应蛋白(CRP)、红细胞沉降率即血沉(ESR)、可溶性细胞间质黏附分子(CAM)、E选择素(s E-SE)水平均显著高于对照组(P<0.05)。观察组CRP、ESR、CAM、s E-SE与AI呈正相关(P<0.05)。结论:炎症反应与类风湿关节炎患者动脉粥样硬化呈正相关,可加快动脉粥样硬化的发生和发展。
Objective: To investigate the effect of inflammatory response on atherosclerosis in patients with rheumatoid arthritis. Methods: Forty-five patients with rheumatoid arthritis were enrolled in the observation group from January 2015 to April 2016; 45 healthy volunteers were selected as the control group. The levels of serum lipids and inflammatory factors were detected and recorded, and the correlation between inflammatory factors and atherosclerosis index (AI) was analyzed. Results: The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and AI in the observation group were significantly higher than those in the control group (P <0.05). The triglyceride (TG) The level of high density lipoprotein cholesterol (HDL-C) was significantly lower than that of the control group (P <0.05). The levels of CRP, erythrocyte sedimentation rate (ESR), soluble intercellular adhesion molecule (CAM), and s-SE in the observation group were significantly higher than those in the control group (P <0.05). The observation group CRP, ESR, CAM, s E-SE and AI was positively correlated (P <0.05). Conclusion: There is a positive correlation between inflammatory reaction and atherosclerosis in patients with rheumatoid arthritis, which can accelerate the occurrence and development of atherosclerosis.