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作者采用双盲试验比较了氟苯咪唑及海群生治疗盘尾丝虫病的效果。患者17例,每例每mg皮肤微丝蚴为15～100条,两组的眼部受损相似,无其它严重的疾病。氟苯咪唑组8例,肌注氟苯咪唑750mg,每周1次,共5周,另服安慰剂药片一天2次,共14天;海群生组9例,先服首剂50mg,以后每剂100mg,一天2次,共14天,另肌注生理盐水,每周1次,共5周。治后均随访12个月。结果:海群生组的皮肤内微丝蚴数在给药的第一周很快下降,以后又渐回升。氟苯咪唑组皮肤微丝蚴数在治疗的最初8周无明显改变,以后逐渐下降,并一直持续在较低水平,在治后12个月微丝蚴平均数为0.2条/mg,显著地低于海群生组(7.3条/mg)。药物引
The authors compared the efficacy of flubenzimid and seaquotrates in the treatment of onchocerciasis in a double-blind trial. Seventeen patients were treated with 15 to 100 microfilariae per 1 mg of skin per milliliter, with similar ocular injuries and no other serious illnesses. Flubendazole group 8 cases, intramuscular injection of fenbendazole 750mg, once a week for 5 weeks, and the other placebo tablets twice a day, a total of 14 days; sea group of 9 cases of first service first serving 50mg, after each 100mg, 2 times a day, a total of 14 days, another intramuscular injection of saline, once a week for a total of 5 weeks. All patients were followed up for 12 months. Results: The number of microfilariae in the skin of the sea group decreased rapidly in the first week after administration, and then gradually rose again. The number of microfilariae in the fenofibrate group did not change significantly during the first 8 weeks of treatment, then decreased gradually and continued at a relatively low level. The average number of microfilariae was 0.2 / mg at 12 months after treatment, significantly Lower than sea group (7.3 / mg). Drug cited