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测定35例肝硬化患者血清胃泌素、胃动素和亮-脑啡肽的含量并讨论其临床意义。其中乙型肝炎后31例、酒精性1例和原因不明3例。伴消化道出血19例、腹水27例、肝性脑病9例和肝肾综合征4例。按肝功能级别(Child分级)分为A级11例,B级19例和C级5例。对照组32例。与对照组比较,肝硬化患者血清胃泌素(128.26±58.24对57.35±23.57ng/L,P<0.01)和胃动素(401.62±189.38对203.19±87.49ng/L,P<0.01)显著升高,亮-脑啡肽无明显改变。血清胃泌素与胃动素升高之间呈正相关(r=0.497,P<0.05)。肝硬化伴或不伴消化道出血、腹水、肝性脑病之间血清胃泌索、胃动素和亮-脑啡肽含量无明显差异(P>0.05),而与肝功能损伤程度有关,即胃泌素和胃动素升高为C级>B级>A级,但无统计学差异(P>0.05)。结果提示测定肝硬化患者血清胃泌素和胃动素含量对病情观察有一定临床意义。
Determination of 35 patients with cirrhosis of serum gastrin, motilin and enkephalin content and to discuss its clinical significance. Among them, 31 cases were hepatitis B, 1 was alcoholic and 3 cases were unknown. 19 cases with gastrointestinal bleeding, 27 cases of ascites, 9 cases of hepatic encephalopathy and hepatorenal syndrome in 4 cases. According to the level of liver function (Child classification) were divided into A grade in 11 cases, B grade in 19 cases and C grade in 5 cases. Control group of 32 cases. Serum gastrin (128.26 ± 58.24 vs 57.35 ± 23.57 ng / L, P <0.01) and motilin (401.62 ± 189.38 vs 203.19 ± 87.49 ng / L, P <0.01) significantly increased in patients with cirrhosis compared with the control group High, bright - enkephalin no significant change. There was a positive correlation between serum gastrin and motilin (r = 0.497, P <0.05). Liver cirrhosis with or without gastrointestinal bleeding, ascites, hepatic encephalopathy serum gastrin, motilin and bright - enkephalin content was no significant difference (P> 0.05), but with the degree of liver damage, namely Gastrin and motilin increased to C grade> B grade> A grade, but no statistical difference (P> 0.05). The results suggest that determination of serum levels of gastrin and motilin in patients with cirrhosis of the disease has some clinical significance.