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目的:研究瘤体内植入125Ⅰ粒子治疗兔VX2肝移植癌的疗效及其病理变化,探讨125Ⅰ粒子组织间植入治疗肝癌的可行性。方法:建立荷瘤兔肝移植癌动物模型。对照组(A组)植入空白剂量(0mCi)125Ⅰ粒子,B组植入1.0mCi125Ⅰ粒子,C组植入0.7mCi125Ⅰ粒子,D组植入0.4mCi125Ⅰ粒子。观察植入前后各组肿瘤体积并计算抑瘤率,切除肿瘤组织进行常规病理检查。结果:各治疗组肿瘤大小在治疗前后比较具有显著差异(P<0.01),均小于同期对照组(P<0.01)。在不同观察时期抑瘤率差别均有统计学意义(P<0.05),治疗1周后抑瘤率变化显著;各个组间抑瘤率差异在治疗后2周最为明显(P<0.01),以后减小,但均高于D组(P<0.01)。病理切片显示靠近125Ⅰ粒子处肿瘤细胞坏死,但远离粒子处仍可见存活肿瘤细胞。1.0mCi粒子对正常肝组织损伤较大。结论:125Ⅰ粒子组织间植入治疗肝癌有效,单个粒子活度以0.7mCi左右较为适宜。
OBJECTIVE: To study the curative effect and pathological changes of 125I seeds implanted in rabbits with VX2 hepatocellular carcinoma and to explore the feasibility of 125I seeds interstitial implantation for hepatocellular carcinoma. Methods: To establish animal model of hepatocellular carcinoma in rabbits. Control group (group A) received a blank dose (0mCi) of 125I particles, group B received 1.0mCi125I particles, group C received 0.7mCi125I particles, and group D received 0.4mCi125I particles. Before and after implantation, the tumor volume was observed and the tumor inhibition rate was calculated. Tumor tissues were excised for routine pathological examination. Results: The tumor size of each treatment group had significant difference before and after treatment (P <0.01), which were all less than the control group (P <0.01). The inhibitory rate of tumor in different observation period was statistically different (P <0.05), and the inhibition rate of tumor in one week after treatment was significantly changed. The difference of inhibition rate in each group was the most obvious at 2 weeks after treatment (P <0.01) Decreased, but both were higher than those in group D (P <0.01). Pathological sections showed that tumor cells near 125I were necrotic, but surviving tumor cells were still visible away from the particles. 1.0mCi particles damage the normal liver tissue. CONCLUSION: The implantation of 125 I seeds is effective for the treatment of liver cancer, and the activity of single particles is about 0.7 mCi.