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目的了解德阳地区妊娠妇女甲状腺功能(甲功)异常的发病率及甲状腺自身抗体的阳性率,为妊娠期甲功异常的早期诊断和干预提供依据。方法选取2014年3月-9月在德阳市人民医院产科门诊就诊的妊娠妇女2 062例作为研究对象,采用电化学发光免疫分析技术检测促甲状腺素(TSH)、游离甲状腺素(FT4)及抗甲状腺过氧化物酶抗体(TPOAb),根据甲功指标分为甲功异常组和甲功正常组。结果 2 062例妊娠妇女中,甲功异常组688例,占33.4%,分别为亚临床甲状腺功能减低(甲减)511例(24.78%),临床甲减114例(5.53%),亚临床甲状腺功能亢进(甲亢)38例(1.84%),临床甲亢25例(1.21%)。甲功异常组和甲功正常组TPOAb阳性率分别为17.73%(122/688)、8.73%(120/1 374),差异有统计学意义(χ2=30.839,P<0.001)。按临床甲减、亚临床甲减、亚临床甲亢、临床甲亢的顺序TPOAb阳性率有增高的趋势(χ2趋势=11.600,P=0.001)。结论德阳地区妊娠妇女甲功异常发生率较高,主要为亚临床甲减,较多合并自身抗体异常。将甲功及抗体检测纳入孕期检查,有利于减少甲状腺疾病对孕妇和胎儿的危害。
Objective To investigate the incidence of abnormal thyroid function (thyroid function) and the positive rate of thyroid autoantibodies in pregnant women in Deyang area, and to provide evidence for the early diagnosis and intervention of abnormal thyroid function in pregnancy. Methods A total of 2 062 pregnant women in obstetrics and gynecology clinics in Deyang People ’s Hospital from March to September of 2014 were selected as research objects. The levels of thyroid - stimulating hormone (TSH), free thyroxine (FT4) and antifunctions Thyroid peroxidase antibody (TPOAb), according to the methyl function index is divided into abnormal thyroid function and normal thyroid function. Results Among 2 062 pregnant women, 688 cases were abnormal thyroid dysfunction, accounting for 33.4%, respectively, which were subclinical hypothyroidism (hypothyroidism) in 511 cases (24.78%), clinical hypothyroidism in 114 cases (5.53%), subclinical thyroid Hyperthyroidism (hyperthyroidism) in 38 cases (1.84%), clinical hyperthyroidism in 25 cases (1.21%). The positive rates of TPOAb in patients with abnormal thyroid function and those with normal thyroid function were 17.73% (122/688) and 8.73% (120/1 374), respectively. The difference was statistically significant (χ2 = 30.839, P <0.001). According to the order of clinical hypothyroidism, subclinical hypothyroidism, subclinical hyperthyroidism and clinical hyperthyroidism, the positive rate of TPOAb increased (χ2 trend = 11.600, P = 0.001). Conclusion The prevalence of abnormal thyroid function in pregnant women in Deyang area is high, mainly in subclinical hypothyroidism and more in patients with abnormal autoantibodies. The Q Gong and antibody testing into pregnancy check, help to reduce thyroid disease in pregnant women and the fetus harm.