海绵相关真菌丛赤壳属HLS206系肉座菌目真菌,分离自我国南海丰肉结海绵。本文对HLS206进行了次生代谢产物研究,通过发酵培养分离得到5个化合物,并应用质谱及一维和二维核磁共振(COSY,HMQC和HMBC)等方法进行结构鉴定,分别确定为chalmicrin(1)、hypocrealesate(2)、岩藻甾醇(3)、豆甾醇(4)和β-谷甾醇(5)。化合物1为首次从肉座菌目真菌中分离获得;化合物2的有关波谱数据为首次报道。 Sponge-related fungus Cong family Corylus HLS206 Department of Hypocrea fungi, isolated from the South China Sea Feng meat sponge. In this paper, we studied the secondary metabolites of HLS206. Five compounds were isolated and purified by fermentation. Their structures were identified by mass spectrometry and one-dimensional and two-dimensional nuclear magnetic resonance (COZY, HMQC and HMBC) and identified as chalmicrin (1) , Hypocrealesate (2), fucosterol (3), stigmasterol (4) and beta-sitosterol (5). Compound 1 was isolated from Hypocrea species fungi for the first time; Compound 2 related spectral data for the first time reported.