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尽管临床应用惰性宫内节育器(IUD)的历史很长,伴随其使用所致的妇女激素变化还不十分清楚,结果仍不一致。本研究对IUD放入前后妇女血清雌二醇、孕酮、催乳素及PGF_(2a)及PGE_2代谢物水平进行了观察。 18名25～36岁健康经产妇女,月经规律,28±2天。产后至少12个月,无口服避孕药及溢乳史。在Saf-T-Coil IUD放入前月经周期及放入后第2个月经周期的8～10小时取静脉血。每3天取样测17β雌二醇、孕酮、13,14-二氢-15酮PGF_(2a)
Despite the long history of using IUDs clinically, the hormonal changes associated with their use are not well understood and the results are still not consistent. In this study, the levels of serum estradiol, progesterone, prolactin, PGF2a and PGE2 metabolites in women before and after IUD insertion were observed. 18 healthy menstruating women aged 25 to 36, menstrual regularity, 28 ± 2 days. Postpartum at least 12 months, no oral contraceptives and history of galactorrhea. Venous blood was taken 8-10 hours after the Saf-T-Coil IUD placed the pre-menstrual cycle and the second post-menstrual cycle. 17β-estradiol, progesterone, 13,14-dihydro-15-keto PGF_ (2a)