肾上腺素能受体可接受其激动剂的刺激产生效应,其作用与交感神经兴奋所致的效果相似。肾上腺素(E)与去甲肾上腺素(NE)均为肾上腺素能受体激动剂,但前者是激素,后者是神经递质,在机体保护自身和适应环境中均起重要作用。肾上腺素能受体有两种不同类型,即α和β,又分别分为α_1、α_2及β_1、β_2亚型,有人将其分为神经受体和激素受体,β_1α_1属前者,β_2、α_2属后者。见图1 对受体的研究常用两种方法,药理的方法是将功能完好的器官或组织,在特殊实验条件下用各种药物试验,得到浓度-效应数据。生化的方法常用放射性配基结合测定法,将器官或组织匀浆,加入放射性配基与其温育,去除未与受体结合的放射性配基,用放射性测定结合 Adrenergic receptors can be stimulated by their agonists to produce effects similar to the effects of sympathetic excitation. Both epinephrine (E) and norepinephrine (NE) are adrenergic receptor agonists, but the former are hormones, the latter being neurotransmitters and play an important role in the body’s protection and adaptation to the environment. There are two different types of adrenergic receptors, α and β, which are divided into α_1, α_2 and β_1, β_2 subtypes, respectively, which are divided into neural receptors and hormone receptors, β_1α_1 former, β_2, α_2 The latter. See Figure 1 Two methods are commonly used to study receptors. The pharmacological approach is to use well-functioned organs or tissues under various experimental conditions to obtain concentration-response data. Biochemical methods commonly used radioligand binding assay, organ or tissue homogenate, adding radioactive ligand incubated with it, to remove the radioactive ligand is not bound to the receptor, radioactive determination of binding