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目的比较不同剂量阿托伐他汀对重度颅内动脉狭窄患者的影响。方法选取2014年2月—2016年2月应城市人民医院收治的重度颅内动脉狭窄患者300例,采用随机数字表法分为对照组和观察组,每组150例。在常规治疗基础上,对照组患者予以低剂量阿托伐他汀(10 mg/d),而观察组患者予以高剂量阿托伐他汀(20 mg/d);两组患者均连续治疗6个月。比较两组患者治疗前后脑血管储存能力、屏气指数及复发率。结果治疗前两组患者脑血管储存能力、屏气指数比较,差异无统计学意义(P>0.05);治疗后观察组患者脑血管储存能力、屏气指数高于对照组(P<0.05);治疗后两组患者脑血管储存能力、屏气指数均高于治疗前(P<0.05)。观察组患者复发率低于对照组(P<0.05)。结论与低剂量阿托伐他汀(10 mg/d)相比,高剂量阿托伐他汀(20 mg/d)可更有效地提高重度颅内动脉狭窄患者脑血管储存能力和屏气指数,降低复发率。
Objective To compare the effects of different doses of atorvastatin on patients with severe intracranial arterial stenosis. Methods 300 patients with severe intracranial arterial stenosis who were admitted to Yingcheng People’s Hospital from February 2014 to February 2016 were randomly divided into control group and observation group with 150 cases in each group. On the basis of conventional treatment, patients in the control group were treated with low-dose atorvastatin (10 mg / d), while those in the observation group were given high-dose atorvastatin (20 mg / d); patients in both groups were treated continuously for 6 months . The cerebral vascular storage capacity, breath hold index and recurrence rate before and after treatment were compared between the two groups. Results There was no significant difference in cerebrovascular storage capacity and breath holding index between the two groups before treatment (P> 0.05). After treatment, the cerebrovascular storage capacity and breath holding index of the observation group were higher than those of the control group (P <0.05) Cerebrovascular storage capacity and breath holding index were higher in both groups than before treatment (P <0.05). The recurrence rate in observation group was lower than that in control group (P <0.05). Conclusions Atorvastatin at a high dose (20 mg / d) can significantly improve cerebrovascular storage capacity and breath holding index in patients with severe intracranial arterial stenosis and reduce recurrence compared with low dose atorvastatin (10 mg / d) rate.