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目的:探讨兰索拉唑和奥美拉唑与抗生素并用治疗酒精型消化溃疡的对比效果。方法:于2013年1月至2015年6月,随机选取57例酒精型消化溃疡患者进行对比研究,采取数字抽签法进行分组,A组35例,B组22例。A组患者给予兰索拉唑联合抗生素治疗,B组患者给予奥美拉唑联合抗生素治疗。对比两组患者的临床疗效。结果:A组的临床总有效率97.14%,明显高于B组81.82%(P<0.05)。A组Hp清除率91.43%,明显高于B组68.18%(P<0.05)。A组不良反应发生率2.86%,明显低于B组22.73%(P<0.05)。A组的生活质量评分(80.24±6.71)分,明显高于B组(67.82±6.03)分(P<0.05)。结论:在酒精型消化溃疡的临床治疗中,相对于奥美拉唑加抗生素方案,兰索拉唑加抗生素方案的临床疗效更加显著。
Objective: To investigate the effect of lansoprazole and omeprazole combined with antibiotics in the treatment of alcoholic peptic ulcer. Methods: From January 2013 to June 2015, 57 patients with alcoholic peptic ulcer were randomly selected for comparison. The patients were divided into three groups according to the method of digital lottery: 35 cases in group A and 22 cases in group B. Patients in group A received lansoprazole combined with antibiotics and patients in group B received omeprazole combined with antibiotics. Compare the clinical efficacy of two groups of patients. Results: The total effective rate of group A was 97.14%, which was significantly higher than that of group B 81.82% (P <0.05). The clearance rate of Hp in group A was 91.43%, which was significantly higher than 68.18% in group B (P <0.05). The incidence of adverse reactions in group A was 2.86%, significantly lower than that in group B (22.73%, P <0.05). The quality of life score of group A (80.24 ± 6.71) was significantly higher than that of group B (67.82 ± 6.03) (P0.05). Conclusion: In the clinical treatment of alcoholic peptic ulcer, the clinical efficacy of lansoprazole plus antibiotics is more significant than that of omeprazole plus antibiotics.