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目的从炎症角度探讨冷浴和喷膜疗法联合应用对大鼠早期烫伤创面的影响。方法选择Wistar大鼠75只,随机分为5组,假致伤组、单纯烫伤组、冷浴组、喷膜组及冷浴喷膜组。伤后观察创面的大体情况,分别取不同时相点的创面标本,用干湿重法测定组织含水量;RIA法检测组织中PGE2的含量。结果研究发现冷浴喷膜疗法能显著减轻创面肿胀,减少创面渗出;在各时相点冷浴组、喷膜组及冷浴喷膜组创面组织含水量和PGE2含量均低于单纯烫伤组(P<0.01),但高于假致伤组(P<0.01);在3个处理组中,冷浴喷膜组上述指标最低,存在统计学差异(P<0.05);单纯烫伤组、冷浴组、喷膜组及冷浴喷膜组创面组织含水量与其PGE2含量存在正相关关系(r=0.739,P<0.001)。结论在浅Ⅱ°烫伤创面局部早期应用冷浴喷膜疗法能减轻创面组织水肿,可能与其抑制局部组织炎症反应存在一定关系。
Objective To investigate the effect of combination of cold bath and sprayed membrane therapy on early scald wounds in rats from the perspective of inflammation. Methods Seventy-five Wistar rats were randomly divided into five groups: sham-injury group, scald group, cold-cooling group, spraying group and cold-spraying group. After wounding, the general condition of the wound was observed. The wound specimens at different time points were taken, the water content of the tissues was measured by the wet-dry method, and the content of PGE2 in the tissues was detected by RIA method. Results The study found that cold spray spray therapy can significantly reduce wound swelling and reduce wound exudation; at each time point in the cold bath group, spray group and cold spray group wound tissue moisture content and PGE2 content were lower than the simple scalded group (P <0.01), but higher than that of the sham injury group (P <0.01). Among the three treatment groups, the indexes in the cold shower spray group were the lowest (P <0.05) There was a positive correlation between wound water content and PGE2 content in bath group, spray group and cold spray group (r = 0.739, P <0.001). Conclusion Early application of cold shower membrane spray therapy in superficial Ⅱ ° scald wounds can reduce wound tissue edema, which may be related to the inhibition of local tissue inflammatory response.