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对４６例光天性肥厚性幽门狭窄（ＣＨＰＳ）和１８例先天性十二指肠梗阻患儿进行胃、食管测压，以探讨上消化道梗阻对食管下端括约肌（ＬＥＳ）功能的影响，结果：两者术前均有ＬＥＳ功能损害，十二指肠梗阻患儿改变更明显；术后７～１０ｄ均有明显恢复，但十二指肠梗阻患儿仍未完全恢复正常。同时，还观察到ＬＥＳ功能损害与发病年龄、病史及呕吐症状轻重有关。将十二指肠梗阻患儿与ＣＨＰＳ患儿的测压结果进行比较可见：前者ＬＥＳ压力明显低于后者，ＬＥＳ高压区长度在十二指肠梗阻时升段和降段长度均有改变，而ＣＨＰＳ患儿只是升段有改变，使ＬＥＳ有效长度缩短，提示胆汁与胃酸混合后比单独胃内容物对食管损害严重。
46 cases of hypertrophic pyloric stenosis (CHPS) and 18 cases of congenital duodenal obstruction in children with gastric esophageal manometry to explore the upper gastrointestinal obstruction on the function of the lower esophageal sphincter (LES), the results: Both preoperative LES dysfunction, children with duodenal obstruction changed more obvious; 7 ~ 10d after surgery were significantly recovered, but children with duodenal obstruction has not fully returned to normal. At the same time, it was also observed that the functional impairment of LES was related to the age of onset, medical history and the severity of vomiting. Comparing the results of manometry and CHPS in children with duodenal obstruction, the former LES pressure was significantly lower than the latter, the length of LES high pressure region in both duodenal obstruction increased and the length of descending segment changed, However, CHPS only had changes in the ascending segment, shortening the effective length of LES, suggesting that the bile mixed with gastric acid had more serious damage to the esophagus than the stomach content alone.