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近年来流行性出血热发病机理的研究有很大进展,但无定论。既往的治疗都根据病程中病理生理和生化改变进行对症治疗。新近由于临床观察和免疫学实验研究的深入,我们用间接免疫荧光法和放射免疫试验证实了流热早期患者血清中有高滴度特异性IgE,并可导致流热病人嗜碱性粒细胞明显地脱颗粒释放组织胺的生物学效应。从而认为由特异性IgE 介导的Ⅰ型变态反应在流热的早期发病机理中可
In recent years, great progress has been made in the study of the pathogenesis of epidemic hemorrhagic fever, but it is inconclusive. Past treatment is based on the pathophysiology and biochemical changes in the symptomatic treatment. Recently, due to the clinical observation and immunological experiments, we used indirect immunofluorescence and radioimmunoassay to confirm the high titer specific IgE in the serum of early stage patients with heat flow and lead to significant basophil effusion Biological effects of degranulation of histamines. It is therefore considered that specific IgE-mediated type I allergic reactions may be at an early stage in the pathogenesis of fluid flow