病人在抗凝治疗的凝血酶原时间,凝血时间及部分凝血激酶时间正常范围的情况下,应用香豆素制剂或肝素之后,仍可引起脑、脊髓或周围神经的出血,甚至导致脑内出血而死亡。因此在用抗凝治疗时应仔细观察,如用双香豆素时必须监测凝血酶原时间,用肝素时监测凝血时间或部分凝血激酶 Patients in the anticoagulant treatment of prothrombin time, clotting time and partial thromboplastin time range, the application of coumarin preparations or heparin, can still cause brain, spinal cord or peripheral nerve hemorrhage, and even lead to intracerebral hemorrhage and death. Therefore, the use of anticoagulant therapy should be carefully observed, such as dicoumarol when prothrombin time must be monitored with heparin when monitoring clotting time or partial thromboplastin