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至今已有较多的工作证明,青霉素具有产生惊厥的药理作用,而苯巴比妥钠则是一种有效的抗惊厥剂。虽然二者的作用机制还不完全清楚,但许多工作表明它们是通过改变中枢神经系统(CNS)中抑制性神经递质——r-氨基丁酸(GABA)的生理活性而发生作用的。文献[7]曾报道了小鼠不同脑区存在着两种GABA摄取系统,即高亲和性及低亲和性GABA摄取系统,并且证明另一种具有抗惊厥药理作用的化合物氨氧乙酸(AOAA)只抑制
So far, more work has been done to prove that penicillin has the pharmacological effect of producing convulsions while phenobarbital sodium is a potent anticonvulsant. Although their mechanisms of action are not fully understood, many work suggests that they work by altering the physiological activity of the inhibitory neurotransmitter, r-aminobutyric acid (GABA), in the central nervous system (CNS). It has been reported in literature [7] that there are two GABA uptake systems in different brain regions of mice, that is, high affinity and low affinity GABA uptake system, and that another compound that has anticonvulsant pharmacological activity, AOAA) only inhibits