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梅毒性冠状动脉口狭窄是心血管梅毒的表现形式之一，常引起严重临床后果。临床通常根据是否具有丰富的冠状动脉侧支循环，是否合并需处理的主动脉瓣反流以及患者耐受性等综合因素决定行冠状动脉旁路移植术或经皮冠状动脉介入治疗，由于梅毒性主动脉炎的持续存在，两种疗法具有移植物吻合口处狭窄和支架内再狭窄的风险，密切随访至关重要。现对近年来国内外梅毒性冠状动脉口狭窄的诊疗进展进行了综述。“,”Syphilitic coronary artery ostial stenosis is one of the manifestations of cardiovascular syphilis, often causing serious clinical consequences. Clinically, coronary artery bypass grafting or percutaneous coronary intervention is performed according to the comprehensive factors including whether the patient has abundant coronary collateral circulation, whether it incorporates aortic valve regurgitation that needs to be treated, and whether the patient can tolerate thoracotomy. Due to the persistent presence of syphilitic aortitis, the two methods exist the risk of graft anastomosis stenosis and intra-stent restenosis, respectively. Therefore, close follow-up is essential. In this article, the progress on diagnosis and treatment of syphilitic coronary artery ostial stenosis at home and abroad in recent years is summarized.