本文报告了1983年10月在北京一幼儿园中由CoxA_(16)肠道病毒引起的手足口病。共发病62例,发病率达32.1%。临床表现为手、足部典型的丘疹、疱疹,口腔粘膜疹和溃疡,平均病程6.46天,预后良好。从17例病人粪便中分离出7株病毒,阳性率41.2%,均为CoxA_(16)肠道病毒。5例病人双份血清有4例中和抗体效价呈4倍增长。 This article reports hand-foot-mouth disease caused by CoxA_ (16) enterovirus in a kindergarten in Beijing in October 1983. A total of 62 cases of disease, the incidence rate of 32.1%. Clinical manifestations of hand, foot typical papules, herpes, oral mucosal rashes and ulcers, the average duration of 6.46 days, the prognosis is good. Seven viruses were isolated from the faeces of 17 patients, with a positive rate of 41.2%, all of which were CoxA_ (16) enterovirus. Four patients in five patients had a 4-fold increase in neutralizing antibody titer.