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目的:观察免疫吸附联合激素和霉酚酸酯治疗重症狼疮性肾炎(LN)的临床疗效。方法:选取40例重症LN患者,按照治疗方法不同,将其分为观察组和对照组,每组20例。对照组给予激素和霉酚酸酯治疗;观察组在对照组基础上联合免疫吸附法治疗,比较两组临床指标改善情况。结果:观察组治疗后的24h尿蛋白、BUN、Scr、ds-DNA、ANA以及SLEDAI评分均明显小于对照组(P<0.05)。结论:在常规激素和霉酚酸酯治疗的基础上联合免疫吸附法治疗重症LN患者疗效显著,临床应用值得推广。
Objective: To observe the clinical effects of combined immunosuppression and mycophenolate mofetil in the treatment of severe lupus nephritis (LN). Methods: Forty patients with severe LN were selected and divided into observation group and control group according to different treatment methods, with 20 cases in each group. The control group was treated with hormone and mycophenolate mofetil. The observation group was treated with the combination of immunoadsorption method on the basis of the control group. The improvement of clinical indexes was compared between the two groups. Results: The urinary protein, BUN, Scr, ds-DNA, ANA and SLEDAI scores of the observation group were significantly lower than those of the control group after treatment (P <0.05). Conclusion: The combination of conventional hormone therapy and mycophenolate mofetil in the treatment of severe LN patients has significant curative effect and clinical application is worth to be popularized.