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目的:探讨长期按需服用伐地那非治疗ED的有效性及安全性。方法:2007年3月至2010年1月,共筛选891例ED患者给予口服伐地那非20 mg,每3天1次,通过电话采用问卷调查的方式进行随访,了解ED患者一般资料,治疗的需求、态度、接受程度;服用药物后均要和伴侣性接触,治疗12周后对临床疗效、不良反应、患者以及伴侣满意度进行调查。结果:完成治疗及随访的700例中,随访504例患者(72%)服用后勃起硬度、持续时间、性生活总体感觉均达到患者满意程度;84例患者(12%)服用后阴茎勃起硬度及持续时间,性生活总体感觉虽有不同程度的改善,但未达到患者满意程度;112例患者(16%)服药前后无明显变化。IIEF-5评分,Rigiscan检测结果及TSS患者伴侣评分与治疗前相比有显著性差异(P<0.05)。服用伐地那非后颜面潮红105例(占15%);头晕头痛70例(占10%);胃肠道反应21例(占3%);鼻塞7例(占1%)。结论:长期按需服用伐地那非可以有效改善ED患者的勃起功能和性交成功率,提高性生活质量,同时患者口服伐地那非安全性及耐受性好。
Objective: To investigate the efficacy and safety of long-term use of vardenafil in the treatment of ED. Methods: From March 2007 to January 2010, a total of 891 ED patients were randomized to receive oral vardenafil 20 mg once daily for 3 days. The patients were followed up by telephone to find out the general information of patients with ED. The attitude, attitude and acceptability of the patients were all reached sexual contact with their partners after taking the drugs. After 12 weeks of treatment, the clinical efficacy, adverse reactions, patients and their satisfaction were investigated. Results: Among the 700 patients who completed the treatment and follow-up, 504 patients (72%) were followed up for erectile stiffness, duration, and overall sexual life satisfaction. The edema hardness of 84 patients (12% Duration, sex life although the overall feeling of improvement to varying degrees, but did not meet the patient satisfaction; 112 patients (16%) before and after taking no significant change. There was significant difference between IIEF-5 score, Rigiscan test and TSS patient comparisons score (P <0.05). After taking vardenafil 105 cases of facial flushing (15%); dizziness and headache in 70 cases (10%); gastrointestinal reactions in 21 cases (3%); nasal obstruction in 7 cases (1%). Conclusion: Long-term demand of vardenafil can effectively improve the erectile function of ED patients and the success rate of sexual intercourse to improve the quality of life, while patients with vardenafil oral safety and well tolerated.