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小于胎龄儿在日后的生活中面临着更高的患肥胖症和代谢性疾病的风险,目前认为这种风险主要与小于胎龄儿出生后生长加速有关。研究人员对奥克兰出生体重协作研究项目中的小于胎龄儿和适于胎龄儿做了研究,测量并计算这些儿童的BMI-Z评分,研究与成人肥胖相关的常见基因变异是否会与小于胎龄儿出生后生长加速有关。研究者将547名欧洲儿童(228名小于胎龄儿和319名适于胎龄儿)进行基因分型,他们被分为共计37个单核苷酸多态性(SNPs)候选基因。重复测量儿童的BMI,并以Z评分法评估肥胖程度,使
Children younger than gestational age are at greater risk of obesity and metabolic disease in later life, and are now considered to be primarily associated with accelerated growth after birth in infants younger than gestational age. Researchers studied small-gestational age and gestational age children in a collaborative research project on birth weight at birth in Auckland, measured and calculated BMI-Z scores for these children to determine whether common genetic variations associated with obesity in adults would be associated with less than fetal The growth of children after birth is accelerated. The researchers genotype 547 European children (228 babies of less than gestational age and 319 gestational age) and divide them into a total of 37 single nucleotide polymorphism (SNPs) candidate genes. Children’s BMI was measured repeatedly, and the degree of obesity was evaluated by Z score