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CD40是一个完整的I型膜糖蛋白, 属TNF受体超家族的成员, 主要表达于抗原提呈细胞 (APC)上。CD154是CD40的配体, 为二型跨膜糖蛋白, 属TNF超家族成员, 主要表达于活化的CD4+ T细胞。CD154 CD40的相互作用可以调节Th1 /Th2型免疫应答。最近的研究显示CD40 CD154的相互作用在
CD40 is a complete type I membrane glycoprotein that is a member of the TNF receptor superfamily and is primarily expressed on antigen presenting cells (APCs). CD154 is a ligand for CD40, a type 2 transmembrane glycoprotein that belongs to the TNF superfamily and is mainly expressed on activated CD4 + T cells. The interaction of CD154 CD40 regulates Th1 / Th2 immune responses. Recent studies have shown that the interaction of CD40 CD154