论文部分内容阅读
目的 对左炔诺孕酮 (LNG)微球的体内释药特性进行研究和评价。方法 用放射免疫法测定生物降解型PLGA(9∶1) LNG微球在大鼠的药代动力学 ,进行了体内外释药试验。结果 该微球具有相似的体内外释药特性 :存在双峰现象 ,双峰之间有一较为平稳的释药区域 ,约占整个释药过程的 70 %。LNG微球在大鼠的MRT约为对照组LNG微晶的 6 .6倍。结论 该微球有比较好的控释作用。依据微球体内外释药的两个特点可对该生物降解型控释微球的质量进行初步控制
Objective To study the in vivo release characteristics of levonorgestrel (LNG) microspheres. Methods The pharmacokinetics of biodegradable PLGA (9:1) LNG microspheres in rats were determined by radioimmunoassay, and the in vitro and in vivo release tests were carried out. Results The microspheres had similar in vitro and in vivo drug release characteristics. There was a bimodal phenomenon. There was a relatively stable drug release region between the two peaks, accounting for about 70% of the total drug release. The MRT of LNG microspheres in rats was about 6.6 times that of the control LNG crystallites. Conclusion The microspheres have a better controlled release. Based on the two characteristics of microspheres both inside and outside the release of the biodegradable controlled release microspheres preliminary quality control