Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

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INTRODUCTIONrnLow back pain (LBP) is a debilitating condition that affects~84%of the population in their lifetime.1 LBP affects physical function, reduces quality of life, and causes psychological distress.2 Although LBP is a multifactorial disease, studies report that intervertebral disc (IVD) degeneration is the main contributing factor.
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