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目的：观察霉酚酸酯（ＭＭＦ）预防尸体肾移植急性排斥反应的疗效及其副反应。方法：共２０例无手术并发症的初次尸肾移植病例，随机分为三组：ＭＭＦ２ｇ／ｄ组１０例，ＭＭＦ１．５ｇ／ｄ组５例，硫唑嘌呤（ＡＺＡ）组５例；各组均同时应用环孢霉素（ＣｓＡ）和强的松（Ｐｒｅｄ）。定期行相关检查，并常规行移植肾活检。结果：ＭＭＦ治疗组经活检证实的急性排斥发生率较低，ＭＭＦ２ｇ组：无（０／１０），ＭＭＦ１．５ｇ组：１例（１／５）；ＡＺＡ组２例（２／５）。移植肾组织化学检查显示，ＭＭＦ治疗组移植肾组织内ＣＤ４＋／ＣＤ８＋浸润细胞数及ＨＬＡ－ＤＲ阳性细胞数低于ＡＺＡ治疗组。应用ＭＭＦ治疗者未发现严重毒副反应，而ＡＺＡ组中有２例发生危及生命的并发症。结论：ＭＭＦ可有效地减少肾移植急性排斥反应的发生，无严重毒副反应。
Objective: To observe the efficacy and side effects of mycophenolate mofetil (MMF) in preventing acute rejection of cadaveric renal allograft. Methods: A total of 20 cases of primary cadaveric kidney transplantation without complications were randomly divided into three groups: 10 in MMF2g / d group, 5 in MMF1.5g / d group and 5 in azathioprine group. Each group Both cyclosporine (CsA) and prednisone (Pred) were used. Regular line inspection, and routine line of renal biopsy. Results: The incidence of acute rejection confirmed by biopsy was lower in MMF2g group than in MMF2g group (0/10), in MMF1.5g group (1/5) and in AZA group (2/5). Transplantation renal histochemical examination showed that the number of CD4 + / CD8 + infiltrating cells and the number of HLA-DR positive cells in the renal allografts of MMF-treated group were lower than that of AZA-treated group. Serious toxicities were not found in patients treated with MMF, whereas 2 in the AZA group had life-threatening complications. Conclusion: MMF can effectively reduce the incidence of acute rejection after renal transplantation without serious side effects.