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目的：比较阿托品（Ａｔｒ），东莨菪碱（Ｓｃｏ），樟柳碱（ＡＴ３）和山莨菪碱（Ａｎｉ）对小鼠行为及记忆损伤作用．方法：行为和记忆实验用开阔和回避反应法．脑Ｍ受体用［３Ｈ］ＱＮＢ测定．结果：Ａｔｒ，Ｓｃｏ和ＡＴ３增加小鼠走动行为２６％－４２％，降低站立，修饰，排便行为５０％－１００％，并抑制开阔记忆．４个药物均能妨碍回避反应．小鼠１８日龄额叶皮层和海马［３Ｈ］ＱＮＢ结合位点数少于３８日龄７％－２３％．结论：１）莨菪类生物碱对小鼠行为和记忆障碍的作用随其日龄增加而减弱．２）Ｓｃｏ对幼年小鼠的行为及记忆障碍作用的最小有效量分别是Ａｔｒ，ＡＴ３和Ａｎｉ的１／１０，１／１００和１／１０００．
Objective: To compare the effects of Atr, Sco, AT3 and Ani on behavior and memory impairment in mice. Methods: Behavioral and memory experiments using open and avoidance response method. Brain M receptor was measured with [<3> H] QNB. Results: Atr, Sco and AT3 increased the walking behavior of mice by 26% -42%, reduced standing, modification and defecation behavior by 50% -100%, and inhibited the open memory. 4 drugs can hinder the avoidance response. The number of [3H] QNB binding sites in the frontal cortex and hippocampus of 18-day-old mice was less than 7% -23% at 38 days of age. Conclusions: 1) The effects of alkaloids on behavior and memory impairment in mice are weakened with the increase of their age. 2) The minimum effective dose of Sco on behavior and memory impairment in young mice is 1/10, 1/100 and 1/1000 of Atr, AT3 and Ani, respectively.