论文部分内容阅读
目的:探讨内镜下氩离子凝固术(APC)联合抑酸治疗对Barrett食管的临床疗效。方法:选择经内镜及病理确诊的Barrett食管患者40例,随机分为两组,治疗组21例,对照组19例,治疗组经内镜下APC治疗后联合埃索美拉唑20mg 2次/日连续3月,对照组单用埃索美拉唑20mg 2次/日连续3月,分别于3月、6月、12月对两组进行临床症状积分和内镜及病理随访。结果:两组治疗后3、6、12月临床症状积分缓解无明显差异性(P<0.05),但从内镜、病理随访的有效率来看,治疗组与对照组相比有显著差异性(P<0.05)。结论:BE内镜下APC联合抑酸治疗能有效逆转Barrett上皮,是一种安全、有效的治疗方法。
Objective: To investigate the clinical efficacy of endoscopic argon plasma coagulation (APC) combined with acid suppression on Barrett’s esophagus. Methods: Forty patients with Barrett’s esophagus diagnosed by endoscopy and pathology were randomly divided into two groups: 21 cases in the treatment group and 19 cases in the control group. The patients in the treatment group were treated with endoscopic APC plus esomeprazole 20 mg twice In March, the control group was treated with esomeprazole 20 mg twice daily for 3 consecutive months. The clinical symptoms, endoscopy and pathology were followed up in March, June and December respectively. Results: There was no significant difference in the relief of clinical symptom scores between the two groups (P <0.05) at 3, 6, and 12 months after treatment, but there was significant difference between the treatment group and the control group (P <0.05). CONCLUSION: The endoscopic BE combined with acid suppression can effectively reverse Barrett’s epithelium, which is a safe and effective treatment.