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目的 :探讨白细胞介素 6 (IL 6 )基因 - 5 97G/A和 - 5 72C/G多态性与湖北地区汉族人群原发性高血压 (EH)的关系。方法 :以人群为基础进行EH病例 对照研究 ,应用PCR RELP技术对 10 2例EH患者和 112例正常对照者的IL 6基因 - 5 97G/A和 - 5 72C/G多态性进行分析。结果 :湖北地区汉族人群IL 6基因 - 5 97位点仅发现有GG基因型 ,未见GA和AA基因型 ;- 5 72位点以CC和CG基因型占优势。EH组 - 5 72CG +GG基因型频率及G等位基因频率分别为 5 9%和 34% ,均显著高于对照组 (P <0 .0 1) ;相对于CC基因型 ,暴露于CG基因型、GG基因型的相对危险度分别为 2 .0 2 (95 %CI:1.15～ 3.5 7,P <0 .0 5 )和 7.12 (95 %CI:2 .18～ 2 3.2 0 ,P<0 .0 1)。EH组不同基因型间总胆固醇、三酰甘油、血糖、体重指数差异均无显著性意义 (P >0 .0 5 )。结论 :湖北地区汉族人群可能不存在IL 6基因 - 5 97G/A多态性 ,而 - 5 72位点CG +GG基因型可能是此人群EH的易感基因型
OBJECTIVE: To investigate the relationship between the polymorphisms of interleukin 6 (IL 6) -597G / A and -572C / G and essential hypertension (EH) in Han nationality in Hubei Province. METHODS: EH case-control studies were conducted on a population-based basis. PCR-based PCR was used to analyze IL-6 97G / A and -572C / G polymorphisms in 102 EH patients and 112 healthy controls. Results: There were only GG genotypes found in locus IL - 5 97 of Han population in Hubei Province, no GA and AA genotypes were found. - CC and CG genotypes were predominant at 5 72 loci. EH group - 5 72CG + GG genotype frequency and G allele frequency were 59% and 34%, respectively, which were significantly higher than that of the control group (P <0.01); Compared with CC genotype, exposure to CG gene (95% CI: 1.15 ~ 3.57, P <0.05) and 7.12 (95% CI: 2.18 ~ 3.220, P <0, respectively), and the relative risk of GG genotype was 2.02 .0 1). There were no significant differences in total cholesterol, triglyceride, blood glucose and body mass index between different genotypes in EH group (P> 0.05). CONCLUSION: IL 6 -597G / A polymorphism may not exist in Han population in Hubei Province, while CG + GG genotype at -572 locus may be the susceptible genotype of EH in this population