以 4 烷基苯乙酮为原料 ,经过Willgerodt反应、水解、酯化、缩合、硼氢化钠还原等 5步反应合成了 2 (4 烷基苯基 ) 1,3 丙二醇。总收率大于 40 % ,产品质量分数均大于 99%。研究了反应物纯度、反应时间及反应温度对 4 戊基苯乙酸甲酯与甲酸甲酯的缩合反应的影响 ,确定了在45℃下、反应 4h为较理想的反应条件。通过红外光谱、核磁共振氢谱和质谱的分析确定了目标化合物的结构 The 2 (4 alkylphenyl) 1,3 - propanediol was synthesized via 4 steps: reaction of Willgerodt, hydrolysis, esterification, condensation and sodium borohydride reduction using 4 - alkylacetophenone as starting material. The total yield of more than 40%, product quality scores were greater than 99%. The effects of reaction mixture purity, reaction time and reaction temperature on the condensation reaction of methyl 4 - pentylphenylacetate with methyl formate were studied. It was found that the reaction conditions were better at 45 ℃ for 4h. The structures of target compounds were confirmed by IR, 1H-NMR and MS-MS