研究临床药代动力学的任务之一是:通过测定较少的血液(或体液)标本,制订比较合理的给药方案。在病人间药动学参数差异比较大的情况下,大家关心的是能不能用一个血液标本来确定给药方案,Ritschel(1977)提出了一点法,该法只适用于肾脏排泄的药物,并且消除速率常数或表观分布容积已知时。Bru- One of the tasks of studying clinical pharmacokinetics is to develop a more rational dosing regimen by measuring less blood (or body fluid) specimens. In patients with large differences in pharmacokinetic parameters, we are concerned about whether a blood sample can be used to determine the dosing regimen. Ritschel (1977) proposed a little law that applies only to drugs excreted by the kidneys and Elimination rate constant or apparent volume of distribution is known. Bru-