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乙肝病毒(HBV)的慢性感染可致肝硬化和肝癌,严重危害着人类身体健康。其X基因编码的蛋白——乙肝病毒X蛋白(HBx)通过与细胞内大量分子的相互作用,参与甚至决定着该过程。本文对近两年来该领域的研究进展作一综述。 1 HBx的性质、分布 HBx是HBV上的X基因编码的16.5KD的分子,有能够与多种蛋白分子发生作用但必须部位相同的氨基酸序列。Fukai等在研究HBV的基因组启动子I时,发现了一个
Chronic hepatitis B virus (HBV) can cause cirrhosis and liver cancer, seriously endangering human health. The X gene encodes the protein - Hepatitis B virus X protein (HBx) through the interaction with a large number of intracellular molecules involved in or even determine the process. This article summarizes the research progress in this area in recent two years. 1 The nature of HBx distribution HBx is a 16.5KD molecule encoded by the X gene on HBV and has an amino acid sequence that is capable of acting on multiple protein molecules but must be identical. Fukai et al. Found one when studying the genomic promoter of HBV