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回顾性研究证明,掌挛缩病、冻肩(肩-手综合征)、Ledderhose综合征、纤维性海绵体炎(阴茎海绵体硬结)、纤维瘤、全身关节疼痛等的发生,与抗癫痫药治疗有关。作者前瞻性研究622例抗癫痫药(卡马西平、苯巴比妥、苯妥英钠和扑痫酮)治疗的患者。治疗6个月以上的406例中,共10例男性发生结缔组织疾病(掌挛缩病、冻肩、纤维性海绵体炎及/或其他关节疼痛),皆见于178例(6%)服用巴比土酸盐的患者,其中服用苯巴比妥的86例中6例、服用扑痫酮的92例中4例;服用卡马西平的107例、服用苯妥英钠的121例中,则无1例发生结缔组织疾
Retrospective studies have shown that the incidence of palmopulmonary contracture, frozen shoulder (shoulder-hand syndrome), Ledderhose syndrome, fibrosolic cavernous inflammation (cavernous sclerosis), fibroma, joint pain, etc., and antiepileptic drugs related. The prospective study of 622 antiepileptic drugs (carbamazepine, phenobarbital, phenytoin sodium and epilepsy) treatment of patients. Of the 406 patients who had been treated for more than 6 months, a total of 10 men developed connective tissue disease (palmoplantar contracture, frozen shoulder, fibrosalgia, and / or other joint pains), all of which were found in 178 (6%) Babb Among the 86 patients who took phenobarbital, 6 patients took phenobarbital, 4 patients took ephedrine ketone, 107 patients took carbamazepine, and none of the 121 patients who took phenytoin Occurrence of connective tissue disease