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目的分析健康人群与人类免疫缺陷病毒(HIV)感染者和艾滋病(AIDS)病人外周血中血常规以及细胞的相关指标存在的差异。方法收集2012年10月至2014年10月于海南省白沙黎族自治县疾病预防控制中心和海南省人民医院接受血常规检查的患者临床资料30例,按照不同的人群分为健康组、HIV感染组、AIDS组三组,每组10例。采用流式细胞仪以及相关检测软件来进行3色、4色的检测,采用AHF HGHIOH54检测仪检测血常规。结果健康组、HIV感染组、AIDS患者三组人群CD_4~+T、CD_3~+T淋巴细胞以及NK细胞指数比较差异有统计学意义(P<0.05)。HIV感染组的CD_3~+T、CD_8~+T细胞计数均高于健康组和AIDS组,差异有统计学意义(P<0.05)。HIV感染组的总淋巴细胞指数(TLC)与健康组比较差异有统计学意义;HIV感染组的单核细胞指数与健康组比较差异有统计学意义(P<0.05),与AIDS组比较差异亦有统计学意义。结论健康人群与HIV感染者和AIDS病人外周血组分有明显差异,其中HIV感染者对血液的影响更为严重。
Objective To analyze the difference of blood routine and cell related index between healthy people and human immunodeficiency virus (HIV) and AIDS patients. Methods Thirty patients were enrolled in the CDC of Hainan Province from October 2012 to October 2014 in Hainan Provincial People’s Hospital for Disease Control and Prevention. The patients were divided into healthy group, HIV-infected group, AIDS group three groups, 10 cases in each group. Using flow cytometry and related detection software for 3-color, 4-color detection, detection of blood by AHF HGHIOH54 detector. Results There were significant differences in CD_4 ~ + T, CD_3 ~ + T lymphocytes and NK cell index between healthy group, HIV infected group and AIDS patients (P <0.05). The counts of CD_3 ~ + T and CD_8 ~ + T cells in HIV infected group were higher than those in healthy group and AIDS group (P <0.05). The total lymphocyte index (TLC) in HIV-infected group was significantly different from that in healthy group (P <0.05). The difference of monocyte index in HIV-infected group was statistically significant (P <0.05) There is statistical significance. Conclusion There are significant differences in peripheral blood components between healthy people and HIV-infected patients and AIDS patients. Among them, HIV-infected patients have a more serious influence on blood.