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目的调查某急性弛缓性麻痹病例是否因为注射甲型肝炎灭活疫苗所引发。方法县级疾病预防控制机构专业人员对病例开展个案调查,收集病例的病历资料,汇总分析后提出诊断意见。结果该病例有脊髓灰质炎疫苗、甲型肝炎灭活疫苗接种的记录。在注射甲型肝炎灭活疫苗后约3 h开始发病,主要症状有发热、双下肢无力等,先后在市级医院和省级医院门诊治疗,主要诊断为病毒性感染,脊髓脱髓鞘病变等;标本中未检出脊髓灰质炎病毒、其他肠道病毒;疫苗质量合格。市级医学会鉴定诊断意见为该病例发生的急性弛缓性麻痹与接种脊髓灰质炎疫苗、甲型肝炎灭活疫苗无关。结论该病例接种甲型肝炎灭活疫苗后发生急性弛缓性麻痹是一种偶合。
Objective To investigate whether a case of acute flaccid paralysis was caused by injection of hepatitis A inactivated vaccine. Methods The county CDC professionals conducted case studies on cases, collected case history data, and summarized the diagnosis before putting forward their opinions. Results The cases were polio vaccine, inactivated hepatitis A vaccination records. The onset of the disease started about 3 hours after the injection of the hepatitis A inactivated vaccine. The main symptoms were fever, weakness in both lower extremities and so on. It was clinically treated in municipal hospitals and provincial hospitals, and was mainly diagnosed as viral infection, demyelinating spinal cord disease, etc. ; No poliovirus and other enteroviruses were detected in the samples; the quality of the vaccine was qualified. Municipal Medical Association identified the diagnosis of the case of acute flaccid paralysis and vaccination with poliomyelitis vaccine, hepatitis A inactivated vaccine has nothing to do. Conclusions Acute flaccid paralysis is a coincidental event after the hepatitis A inactivated vaccine is inoculated in this case.