论文部分内容阅读
目的探讨肿瘤坏死因子（TNF）和可溶性肿瘤坏死因子受体（STNFR）与膀胱肿瘤生物学行为的关系。方法测定26例膀优移行细胞癌患者和20例正常对照者血清中TNF和STNFR水平。结果发现膀胱肿瘤患者血TNF水平与对照组相比差异无显著性（P＞0．05），而STNFR水平显著高于对照组（P＜0．001），并随着临床分期的增加而升高，巨术后2周时显著下降（P＜001）；TNF与STNFR水平之间无显著相关关系。结论STNFR抑制了TNF生物学活性而降低了机体的免疫功能，并可作为评估病情严重程度和预后的指标。
Objective To investigate the relationship between tumor necrosis factor (TNF) and soluble tumor necrosis factor receptor (STNFR) and the biological behavior of bladder tumor. Methods The serum levels of TNF and STNFR in 26 patients with transitional cell carcinoma of the bladder and 20 normal controls were measured. The results showed that there was no significant difference in TNF level between the two groups (P> 0.05), while the level of STNFR in bladder cancer patients was significantly higher than that in control group (P <0.001), and increased with the increase of clinical stage There was no significant correlation between TNF and STNFR levels after 2 weeks of treatment (P <0.001). Conclusion STNFR can inhibit the biological activity of TNF and reduce the immune function of the body, and can be used as an indicator to evaluate the severity and prognosis of the disease.