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以自行研制的手持式γ探测器及１３１Ｉ标记的抗ＣＥＡ单克隆抗体Ｃ５０，对１６例胃癌患者进行了放射免疫导向手术（ＲＩＧＳ）。ＲＩＧＳ判断原发癌灶及胃壁浸润的敏感性为９０．５％，特异性为８８．９％，正确率为８９．５％。对胃区域淋巴结转移判断的敏感性为９２．６％，特异性为８５．７％，正确率为８８．２％。判断淋巴结转移的正确率显著高于视触诊（６２．９％）及碳墨染色（４７．１％、Ｐ＜０．０１）。研究结果表明：本ＲＩＧＳ系统能正确判断胃癌原发灶，胃壁浸润及区域淋巴结转移范围，有助于更合理实施胃癌根治术。
Using self-developed handheld gamma detector and 131I-labeled anti-CEA monoclonal antibody C50, 16 patients with gastric cancer were subjected to radioimmunoguided surgery (RIGS). RIGS showed a sensitivity of 90.5%, a specificity of 88.9%, and a correct rate of 89.5% for the primary tumor and gastric infiltrate. The sensitivity of the judgment of gastric lymph node metastasis was 92.6%, the specificity was 85.7%, and the correct rate was 88.2%. The correct rate of lymph node metastasis was significantly higher than that of visual palpation (62.9%) and carbon ink staining (47.1%, P<0.01). The results of the study indicate that this RIGS system can correctly determine the primary lesions of the gastric cancer, the infiltration of the stomach wall, and the extent of regional lymph node metastasis, which is helpful for more reasonable radical gastrectomy.