论文部分内容阅读
目的探讨fascin在乳腺癌发病过程中的作用。方法用免疫组化方法检测20例乳腺导管上皮单纯性增生、9例乳腺导管上皮非典型性增生、25例乳腺浸润性导管癌患者中fascin的表达。结果Fascin在单纯性增生、非典型性增生、浸润性导管癌中的阳性率分别为95%、22.2%、8%。Fascin在导管上皮单纯性增生中的表达明显高于非典型性增生和浸润性导管癌(P<0.01)。结论Fascin在乳腺增生向乳腺癌的进展过程中可能起着某种作用,但目前尚难以作为乳腺癌诊断的分子标志。
Objective To investigate the role of fascin in the pathogenesis of breast cancer. Methods Immunohistochemical method was used to detect the expression of fascin in 20 cases of ductal hyperplasia, 9 cases of atypical hyperplasia of breast ductal epithelium and 25 cases of invasive ductal carcinoma of the breast. Results The positive rates of Fascin in simple hyperplasia, atypical hyperplasia and invasive ductal carcinoma were 95%, 22.2% and 8%, respectively. The expression of Fascin in ductal hyperplasia was significantly higher than that in atypical hyperplasia and invasive ductal carcinoma (P <0.01). Conclusion Fascin may play a role in the progression of breast hyperplasia to breast cancer, but it is still not as a molecular marker for the diagnosis of breast cancer.