目的：研究他克林的双体衍生物双（７）他克林对东莨菪碱引起的大鼠记忆障碍的影响．方法：采用大鼠Ｍｏｒｉｓ水迷宫固定平台的程序研究空间记忆．以他克林为对照药．结果：东莨菪碱（０３ｍｇ·ｋｇ－１，ｉｐ）使大鼠到达平台的潜伏期明显长于生理盐水对照组．双（７）他克林（０３５μｍｏｌ·ｋｇ－１，ｉｇ或ｉｐ）和他克林（８５２μｍｏｌ·ｋｇ－１ｉｇ；４２６μｍｏｌ·ｋｇ－１ｉｐ）均可对抗东莨菪碱导致的空间记忆障碍；在灌胃及腹腔注射途径下，双（７）他克林的效价，分别强于他克林２４及１２倍．结论：双（７）他克林明显改善东莨菪碱导致的空间记忆障碍，其作用强于他克林． OBJECTIVE: To study the effect of tacrine’s bis (7) tacrine on scopolamine-induced memory impairment in rats. METHODS: Spatial memory was studied using the Moris water maze fixed platform protocol. Tacrine as a reference drug. Results: Scopolamine (03 mg · kg-1, ip) had a significantly longer latency to reach the platform than the saline control group. Scopolamine-induced spatial memory could be countered by either bis (7)  tacrine (035 μmol · kg-1, ig or ip) and tacrine (852 μmol · kg-1 and 426 μmol · kg-1 ip) Obstacles; In gavage and intraperitoneal injection, double (7)  tacrine titers were stronger than tacrine 24 and 12 times. Conclusion: Double (7)  tacrine significantly improves scopolamine-induced spatial memory impairment, its effect is stronger than tacrine.